Biostream
Biostream
Biostream International B.V. is a Dutch-based manufacturer specializing in bioprocessing equipment, including bioreactors, laboratory fermenters, photobioreactors, and incubator shakers. Its systems support applications ranging from laboratory research and process development to pilot-scale and production-scale fermentation.
Biostream combines bioprocess engineering, process control, customization, and technical expertise to provide solutions for research, biotechnology, pharmaceutical, biopharmaceutical, and industrial applications.
Bioreactors, Fermenters & Photobioreactors
Laboratory Bioreactor Systems
Biostream laboratory bioreactors are designed for research, development, cultivation studies, and process optimization, with systems available across different working volumes.
- Lab-Scale Bioreactors: Bioreactor systems from 50 ml to 15 liters for laboratory research and process development, with precise control of parameters including pH, temperature, and dissolved oxygen.
High-Performance Fermenter Systems
Biostream Laboratory Fermenters and pilot-scale fermenters support process development and scale-up while maintaining controlled cultivation conditions.
- Pilot-Scale Fermenters: Systems from 15 liters to several hundred liters for process scale-up, with controlled monitoring of process parameters.
Advanced Fermenter for Laboratory
Biostream provides advanced fermentation systems for laboratory, pilot, and industrial-scale production applications.
- Production-Scale Systems: Customizable fermentation systems with volumes up to 15 m³, including options such as Clean-In-Place (CIP) and Ultra-High Temperature (UHT) processing.
Specialized Equipment
- Photobioreactors: Designed for algae cultivation with controlled LED lighting, gas mixing, and temperature regulation to support optimized growth conditions.
- Cell Culture Bioreactors: Designed for mammalian and insect cell cultivation, providing controlled and sterile process environments.
- Custom Solutions: Biostream develops customized bioreactor and fermentation systems according to specific application, process, monitoring, and control requirements.
Models and features
Bio EZ — “Smart Simplicity for Serious Science”
The Bio EZ is an entry-level laboratory bioreactor designed for straightforward bioprocessing. It provides a budget-friendly, low-CAPEX solution for startups, researchers, and small-scale producers.
- Vessel and Volume: Autoclavable borosilicate jacketed/non-jacketed glass vessels and 316 L stainless steel vessels. Working volumes range from 0.2 L to 7.0 L depending on the vessel configuration.
- Agitation: Mechanical motor drive with two Rushton impellers and speeds up to 1200 RPM.
- Aeration: Standard Mass Flow Controller (MFC) for air, with options for O₂, N₂, and CO₂.
- Pumping: Four integrated peristaltic pumps with a flow range of 0.1–50 ml/min.
- Temperature Control: Temperature range from 5°C above room temperature to 70°C, with an optional 80°C short-duration range. An optional chiller can extend cooling to 15°C below room temperature.
BioCompact — “Parallel Power for Smarter Selection”
The BioCompact is a laboratory bioreactor system designed for high-efficiency R&D, strain optimization, and parallel cultivation.
- Parallel Processing: Designed for parallel cultivation and high-throughput research workflows.
- Stackable Design: Stackable configuration helps maximize laboratory space while operating multiple units.
- Volume Range: Autoclavable borosilicate jacketed/non-jacketed glass vessels with working volumes from 0.25 L to 7.5 L.
- Customizability: Selected options can be configured to meet specific process requirements.
BioBench — “Limitless Configurations at Lab Scale”
Total Volume: 2–13 L; Microbial / Cell Culture
The BioBench is a highly customizable benchtop bioreactor system for laboratory-scale microbial and cell culture applications.
- Most customizable unit in the benchtop product line.
- Autoclavable borosilicate jacketed and non-jacketed glass vessels.
- Stainless steel vessels with Sterilizing in Place (SIP).
- Compatible with most available single-use vessel types up to 13 L.
- Designed for operation under pressure up to 6 Bar.
BioBench Twin — “Double Capacity and parallel production”
Working Volume: 2–13 L; Glass; Cultivation of bacteria, algae, cells, and fungi
The BioBench Twin provides a dual-reactor configuration for parallel cultivation and increased experimental capacity while maintaining a compact laboratory footprint.
- Most customizable unit in the benchtop product line.
- Autoclavable borosilicate jacketed and non-jacketed glass vessels.
- Stainless steel vessels with Sterilizing in Place (SIP).
- Compatible with most available single-use vessel types up to 13 L.
- Designed for operation under pressure up to 6 Bar.
BioTwin Pilot Scale — “Double Capacity, Clean Design”
Working Volume: 15–50 L; Stainless Steel
The BioTwin Pilot Scale is a compact stainless-steel pilot-scale bioreactor system designed to control one or two vessels.
- Compact design for laboratory and pilot-scale applications.
- Can be upgraded from a single-vessel to a dual-vessel configuration.
- 15-inch touchscreen interface.
- PLC-level touchscreen controller with inputs for temperature, stirring, pH, pO₂, redox, liquid level, gas flow, pressure, biomass, current, and voltage.
- Supports 12 analog signals, 24 digital signals, and 32 Modbus connections for drive and control expansion.
- Can connect to monitoring software through OPC protocol.
- Open water-loop temperature control.
- Fully automatic cooling, heating, and sterilization system.
BioPilot — Large Scale in Situ Sterilization and Fermentation System
Working Volume: 3–3000 L; Stainless Steel; Applications: Bacteria, Cells, Algae, and Fungi
The BioPilot provides large-scale fermentation and bioreactor systems for process development and production applications.
- Total reaction volumes from 3 L to 3000 L.
- Stainless steel fermentation systems.
- Suitable for bacteria, cell, algae, and fungi cultivation.
- Flexible system configuration according to available laboratory or production space.
- Designed for large-scale fermentation and bioprocess applications.
BOS 3.0
BOS 3.0 is Biostream’s bioreactor control and bioprocess software platform, combining process control, recipe automation, device integration, and data management in one system.
Process Control and Automation
- Advanced Recipes: Programmable multi-step sequences with conditional logic, loops, and process dependencies.
- Global Variables: Enables synchronization of selected information between connected reactors.
- Cascade Logic: Supports standard PID cascade control and advanced cascade logic.
- Modular Programs: Multiple process configurations can be stored and executed independently.
- Runtime Sterilization: Supports sterilization of transfer lines while fermentation is running.
Consistency and Seamless Scale-Up
- One Software, All Scales: Consistent interface and logic across laboratory, pilot, and production-scale bioreactors.
- Linear Scale-Up: Process programs can be transferred between bioreactor systems to support scale-up.
- Adaptive UI: Displays functions and controls relevant to the specific bioreactor configuration.
Usability and Multimedia Integration
- Multimedia Integration: Videos, images, SOPs, training material, and maintenance information can be integrated into the interface.
- Multi-Language Support: Multiple interface languages can be configured for individual users.
- Preconfigured Device Templates: Profiles for sensors and pumps support faster system configuration and data logging.
- User Group Management: User access rights can be configured for different roles.
- Network Communication: Enables data exchange between connected bioreactor systems.
- Smart Diagnostics: Supports remote troubleshooting through system diagnostics.
- Remote Application Support: Enables experts to review audit information and provide application guidance.
BIOVIB EZ Standard — Basic Incubator Shaker
The BIOVIB EZ Standard is a professional-grade, budget-conscious incubator shaker designed for research laboratories, startups, and small-scale bioprocessing applications.
Primary Applications: Microorganism cultivation including bacteria, yeast, and fungi, as well as insect cell culture.
Key Features
- Plug-and-Play: Designed for straightforward operation.
- Drive System: Belt-driven shaking system designed for low noise and minimal vibration.
- Design & Modularity: Stackable design for up to three units, with a downward-opening door that also functions as a loading shelf.
- Construction: Anti-corrosion materials for durability and easy cleaning.
- Technical Specifications: Shaking speed from 20–400 rpm with a fixed 25 mm shaking diameter.
BIOVIB EZ High End — Advanced Incubator Shaker
The BIOVIB EZ High End is an advanced incubator shaker for pharmaceutical and biotechnology applications from R&D through production environments.
Primary Applications: Supports microbial and insect cell cultivation and provides enhanced control options for mammalian, plant, and algal cultures.
Advanced Features
- Magnetic Drive: Beltless magnetic drive designed for hygienic operation, energy efficiency, low vibration, and negligible heat generation.
- Stainless Steel Interior: Full stainless-steel interior similar to a CO₂ incubator.
- Environmental Control: Optional active CO₂ control and humidification up to 85% relative humidity.
- Flexible Shaking: Cell culture version with a 50 mm throw and fermentation version with a 25 mm throw.
- Decontamination: Optional UV or H₂O₂ disinfection, with UV sterilization capable of operating during cultivation.
CO₂ Incubator
Biostream offers CO₂ incubators for animal cell, microbial, and specialized tissue cultivation, along with cell culture incubator shakers featuring integrated CO₂ control.
Biostream static incubators are available in different configurations according to cooling and atmospheric control requirements.
- Standard CO₂ Incubator Series: Air-jacketed units from 40 L to 1200 L, operating from Ambient +5°C to 60°C with six-sided direct heating.
- Peltier-Cooled CO₂ Incubators: Units from 40 L to 850 L operating from 20°C to 60°C, using Peltier technology for temperature control.
- Tri-Gas Incubators (CO₂/O₂/N₂): Units from 40 L to 850 L with oxygen control from 0.6% to 85%, suitable for specialized cell culture applications.
Core Features of the Static Series
- Precision Sensing: Dual-beam IR CO₂ sensor for fast and precise CO₂ measurement.
- Decontamination: Selected models offer optional 125°C dry hot-air sterilization without removing the CO₂ sensor.
- Humidification & Safety: Natural humidification water tray system with heated front door and frame to help prevent condensation.
- User Interface: 7-inch TFT touchscreen with real-time data display and USB historical data storage.
Incubator Shakers with CO₂ Control
The BIOVIB EZ High End Cell Culture Version combines controlled shaking with CO₂ and humidity control for sensitive cell culture applications.
Application: Designed for mammalian, plant, and algal cultures where controlled atmospheric conditions and active pH adjustment are required.
- Technical Control: Dual-beam IR sensor with a CO₂ measurement range of 0.1–20%.
- Humidity Control: Relative humidity up to 85% to reduce sample evaporation.
- Flexible Scaling: Stackable configuration up to three decks.
- Magnetic Drive: Beltless magnetic drive designed to generate negligible heat and minimize its effect on temperature-sensitive cell cultures.
FAQs
A bioreactor is a vessel that supports controlled biological reactions for producing bio-products like pharmaceuticals and biofuels.
Bioreactors offer better control over the production environment, improving the consistency and quality of the product. They enhance yield, reduce contamination risks, and allow for scalable production in industries like biotechnology, agriculture, and pharmaceuticals.
we have 5 types include BioCompact Multiple Reactor, BioBench Twin, BioBench, BioProject and BioPilot, each suited for different production needs.
Labquip Asia offers tailored bioreactor systems, providing expert guidance and solutions for efficient biological production, ensuring high performance and reliability for various industrial applications.
They support microbial and cell growth by controlling pH, oxygen, temperature, and nutrients.
Fermenters range from small lab-scale (50 ml) to large production-scale systems (up to 15 m³).
They are widely used in pharmaceuticals, biotech, food, beverages, and agriculture.
Most systems include Clean-in-Place (CIP) features for easy cleaning and sterilization.